International Journal of Scientific & Technology Research

Home About Us Scope Editorial Board Blog/Latest News Contact Us
10th percentile
Powered by  Scopus
Scopus coverage:
Nov 2018 to May 2020


IJSTR >> Volume 3- Issue 12, December 2014 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

X-Ray Breast Brachytherapy Instead Of 192Ir Mammosite Balloon Brachytherapy

[Full Text]



Mahmoud Suleiman Ahmed Dahoud, Iskandar Shahrim Mustafa



Index Terms: Brachytherapy, MammoSite brachytherapy, electronic brachytherapy



Abstract: Efforts nowadays are looking for the tumor itself and organs surrounding it to give high doses to tumor itself with low doses to adjacent organs. The researchers found that the use of a new technology uses x ray techniques can offer some of what they are looking for. It can be used in cases of small distance between the breast skin and the edge of the lumpectomy cavity. The low energy used by x-ray source is an advantage for sparing sensitive organs around the tumor cavity.



[1] A. G. Underbrink, A. M. Kellerer, R. E. Mills, and A. H. Sparrowt, ” Comparison of X-Ray and Gamma-Ray Dose-Response Curves for Pink Somatic Mutations in Tradescantia Clone 02”, Rad. and Environm. Biophys, vol.13, pp.295-303, 1976.

[2] S.L. Kakani, and A. Kakani”Material Science”, 2006, pp.259, New Age International, Delhi.

[3] P. Sprawls, ” The Physical Principles of Medical Imaging”, 2nd Ed, 1995, available at http://www.sprawls.org/resources, accessed on 15 Nov.2014.

[4] J.B. Wojcicka, D. E. Lasher, R. Malcom, and G.Fortier, “Clinical and dosimetric experience with MammoSite-based brachytherapy under the RTOG 0413 protocol” journal of applied clinical medical physics, vol. 8, no. 4, pp. 176-184, fall 2007.

[5] J. F. Dempsey, J. A. Williams, J. B. Stubbs, T. J. Patrick, and J. F. Williamson, ” Dosimetric properties of a novel brachytherapy balloon applicator for the treatment of malignant brain-tumor resection-cavity margins”, International Journal of Radiation Oncology * Biology * Physics Vol. 42, Iss. 2 , pp. 421-429, 1 Sep. 1998

[6] M. M. Mille, X. G. Xu, and M. J. Rivard, ” Comparison of organ doses for patients undergoing balloon brachytherapy of the breast with HDR 192Ir or electronic sources using Monte Carlo simulations in a heterogeneous human phantom”, Med Phys, vol.37, no. 2, pp 662–671, Feb. 2010.

[7] A. Dickler , M.C. Kirk , N. Seif , K. Griem , K. Dowlatshahi , D. Francescatti , and R.A. Abrams, ” A dosimetric comparison of MammoSite high-dose-rate brachytherapy and Xoft Axxent electronic brachytherapy”, Brachytherapy.. Vol. 6, no.2, pp 164-168. Apr-Jun2007

[8] P.R. Benitez, M.E. Keisch, F.Vicini, A.Stolier, T.Scroggins, A.Walker, J.White, P.Hedberg, M. Hebert, D.Arthur, V. Zannis, C. Quiet, O. Streeter, and M. Silverstein, ”Five-year results: the initial clinical trial of Mammosite balloon brachytherapy for partial breast irradiation in early-stage breast cancer”, The American Journal of Surgery, Vol. 194, Iss. 4 , pp. 456-462, October 2007.

[9] B. Kassas, F. Mourtada, J.L. Horton, R.G. Lane, T.A. Buchholz, and E. A. Strom, ” Dose modification factors for 192Ir high-dose-rate irradiation using Monte Carlo simulations”, Journal of Applied Clinical Medical Physics, vol. 7, no. 3, summer 2006.

[10] M. Keisch, F. Vicini, R. R. Kuske, M. Hebert, J. White, C. Quiet, D. Arthur, T. Scroggins, and O. Streeter, ” Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy”, International Journal of Radiation Oncology*Biology*Physics, Vol. 55, Iss. 2, pp. 289–293, 1 February 2003

[11] K. Dowlatshahi, H.C. Snider, M. A.Gittleman, C. Nguyen, P. M. Vigneri, and R. L. Franklin, “Early Experience with Balloon Brachytherapy for Breast Cancer Free”. Arch Surg, vol. 139, no. 6, pp.603-608, 2004.

[12] T.Major, P. Niehoff, G. Kovács, J. Fodor, and C. Polgár, ”Dosimetric comparisons between high dose rate interstitial and MammoSite balloon brachytherapy for breast cancer”, Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, vol.79, no.3, pp321-328, 2006.

[13] P. Niehoff , C. Polgár, H. Ostertag, T. Major, Z. Sulyok, B. Kimmig, and G. Kovács, ” Clinical experience with the MammoSite radiation therapy system for brachytherapy of breast cancer: results from an international phase II trial”, Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, vol. 79, no. 3, pp.316-320, 2006.

[14] U. Veronesi, A. Luini, M. D. Vecchio, M. Greco, V. Galimberti, M. Merson, F. Rilke, V. Sacchini, R. Saccozzi, T. Savio, R. Zucali, S. Zurrida, and B. Salvadori, ”Radiotherapy after Breast-Preserving Surgery in Women with Localized Cancer of the Breast”, N Engl J Med, vol. 328, pp.1587-1591, 1993.

[15] G. K. Edmundson, F. A. Vicini, P. Y. Chen, C. Mitchell, and A. A. Martinez, ” Dosimetric characteristics of the MammoSite RTS, a new breast brachytherapy applicator”, International Journal of Radiation Oncology*Biology*Physics, vol. 52, iss. 4, pp. 1132–1139, 15 March 2002.

[16] P. Niehoff, B. Ballardini, C. Polgár, T. Major, J. Hammer, A. Richetti, and G. Kovács, “Early European experience with the MammoSite radiation therapy system for partial breast brachytherapy following breast conservation operation in low-risk breast cancer”, Breast, vol.15, no.3, pp.319-325, 2006.

[17] A.E.Dragun, E.G.Aguero, J.F.Harmon , J.L.Harper, and J.M.Jenrette, ” Chest wall dose in MammoSite breast brachytherapy: radiobiologic estimations of late complication risk based on dose-volume considerations”, Brachytherapy, vol.4, no.4, pp.259-263, 2005.

[18] C. Laino, “Balloon Brachytherapy May Prevent Breast Cancer Relapse”, Oncology Times, ASTRO Annual Meeting, vol. 27, iss.23, pp. 49-50, 10 December 2005. doi: 10.1097/01.COT.0000290087.76629.45

[19] D. Kusserow, A. J. Zauls, G. Onicescu, J. A. Fortney, A. Irshad, J. L. Harper, and E. G. Mayer, ” Risk of needle aspiration/biopsy, seroma formation, and unscheduled radiographic imaging during surveillance period for balloon brachytherapy patients versus patients treated with whole-breast irradiation”, ASCO American Society Of Clinical Oncology, 2010, available at http://www.asco.org.

[20] R. Sanglap “Are New Cancer Treatments Worth the Cost?”, International Business Times , January 5, 2012 , available at http://au.ibtimes.com/articles/276598/20120105/new-cancer-treatments-worth-cost.htm#.

[21] A. Dickler , M.C.Kirk , J. Chu, and C. Nguyen, ” The MammoSite breast brachytherapy applicator: a review of technique and outcomes”, Brachytherapy, vol.4, no.2, pp.136-136 2005.

[22] A.Dickler, ” Xoft Axxent electronic brachytherapy: a new device for delivering brachytherapy to the breast”, Nat Clin Pract Oncol, vol.6, no.3, Mar. 2009.

[23] A. Dickler , K. Dowlatshahi, ” Xoft Axxent electronic brachytherapy”, Expert Rev Med Devices, vol.6, no.1, pp.27-31, Jan. 2009.

[24] J.T.Hepel , J.R.Hiatt, G.A. Cardarelli, and D.E.Wazer, ” Modeling study for optimization of skin dose for partial breast irradiation using Xoft Axxent electronic brachytherapy applicator”, Brachytherapy, vol.9, no.1, pp.81-85, Jan-Mar. 2010.

[25] AAPM, ”Fabrication of Miniature X-ray Tube using Carbon Nanotube Field Emitter for Electronic Brachytherapy” , available at http://www.aapm.org/meetings/amos2/pdf/59-15747-15249-456.pdf , accessed at 14Nov.2014. Abstract ID: 15747.

[26] A. Dickler, M. C. Kirk, N. Seif, K. Griem, K. Dowlatshahi, D. Francescatti, and R. A. Abrams, “A dosimetric comparison of MammoSite high-dose-rate brachytherapy and Xoft Axxent electronic brachytherapy”, Brachytherapy, vol. 6, pp.164–168, 2007.

[27] O'Shaughnessy, Axxent Electronic Brachytherapy System. United States Food and Drug Administration. Dec 2005.Available at :http://www.accessdata.fda.gov/cdrh_docs/pdf5/K050843.pdf, accessed at 14 Nov. 2014.

[28] A. Dickler, M.C.Kirk , A. Coon , D. Bernard, T. Zusag, J. Rotmensch, D.E.Wazer, ” A dosimetric comparison of Xoft Axxent Electronic Brachytherapy and iridium-192 high-dose-rate brachytherapy in the treatment of endometrial cancer”, Brachytherapy, vol.7, no.4, pp.351-354, Oct-Dec 2008.

[29] A. Dickler, M.Y. Puthawala, J. P. Thropay, A. Bhatnagar and G. Schreiber, ”Prospective multi-center trial utilizing electronic brachytherapy for the treatment of endometrial cancer”, Radiat Oncol, vol.5, no.67, pp.1-6, Jul. 2010. doi: 10.1186/1748-717X-5-67. Available at http://www.biomedcentral.com/content/pdf/1748-717x-5-67.pdf.

[30] P. Beitsch, F. Vicini, M.Keisch, B. Haffty , S. Shaitelman, and M.Lyden, ”Five-year outcome of patients classified in the "unsuitable" category using the American Society of Therapeutic Radiology and Oncology (ASTRO) Consensus Panel guidelines for the application of accelerated partial breast irradiation: an analysis of patients treated on the American Society of Breast Surgeons MammoSite Registry trial”. Ann Surg Oncol. Vol.3, pp.219-252, Oct. 2010.

[31] C.C.Park, S.S.Yom, M.B.Podgorsak, E.Harris, R.A.Price, A.Bevan, J.Pouliot, A.A.Konski, and P.E.Wallner, ” American Society for Therapeutic Radiology and Oncology (ASTRO) Emerging Technology Committee report on electronic brachytherapy” Int J Radiat Oncol Biol Phys, vol.76, no.4, pp.963-972. Mar. 2010.

[32] S. Ahmad , D. Johnson , J.R. Hiatt, D.T. Still, E.E. Furhang, D. Marsden, F. Kearly, D.A. Bernard, and R.W. Holt, ” Comparison of tumor and normal tissue dose for accelerated partial breast irradiation using an electronic brachytherapy eBx source and an Iridium-192 source”, J Appl Clin Med Phys, vol.11, no.4, pp.3301, Sep. 2010.

[33] Clinical Policy Bulletin: Brachytherapy, Aetna, No. 0371, 6 Jun. 2012, available at http://www.aetna.com/cpb/medical/data/300_399/0371.html, accessed at 14 Nov.2014.

[34] P.D. Beitsch, R.R. Patel, J.D. Lorenzetti, J.C. Wurzer, J.C. Tucker, S.J. Laduzinsky, and M.A. Kugler. “Post-surgical treatment of early-stage breast cancer with electronic brachytherapy: an intersociety, multicenter brachytherapy trial”, Onco Targets Ther, vol.3, pp. 211-218, Oct. 2010.

[35] A. Bhatnagar, and A. Loper, ” The initial experience of electronic brachytherapy for the treatment of non-melanoma skin cancer”, Radiat Oncol, vol.5, no.87, pp.1-8, Sep.2010. doi: 10.1186/1748-717X-5-87.

[36] R.R. Patel, P.D. Beitsch, T.D. Nichols, J.D. Lorenzetti, J.C. Wurzer, J.C. Tucker, G.W. Nunn, S.J. Laduzinsky, M.A. Kugler, D.L. Simmons, M.S. Gilligan, T. Roy, J.K. Foley, J.P. Thropay, M.W. Odou, B.A. Bornstein, P.E. Tito, M. Chadha, S.K. Boolbol, S.C. Lane, and J.G. White, ” Postsurgical Treatment of Early-stage Breast Cancer With Electronic Brachytherapy: Outcomes and Health-related Quality of Life at 1 Year”, Am J Clin Oncol, vol.36, no.5, pp.430-435, Oct.2013. doi: 10.1097/COC.0b013e31825493bb.

[37] A. Dickler, M.C. Kirk, N. Seif, K.Griem, K. Dowlatshahi, D. Francescatti, and R.A.Abrams, ” A dosimetric comparison of MammoSite high-dose-rate brachytherapy and Xoft Axxent electronic brachytherapy”, Brachytherapy, vol.6, no.2, pp.164-168, Apr-Jun 2007.

[38] W. C. Dooley, O. Algan, K. Dowlatshahi, D. Francescatti, E. Tito, J D. Beatty, A. G. Lerner, B. Ballard and S. K. Boolbol, ”Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer”, World Journal of Surgical Oncology, vol. 9, no.30, 2011.

[39] W.C. Dooley, J.P. Thropay, G.J. Schreiber, M.Y. Puthawala, S.C. Lane, J.C. Wurzer, C.E. Stewart, G.L. Grado, H.G. Ahuja, G.M. Proulx, ” Use of electronic brachytherapy to deliver postsurgical adjuvant radiation therapy for endometrial cancer: a retrospective multicenter study”, Onco Targets Ther, vol.5, no.3, pp. 197-203, Oct. 2010.

[40] W.C. Dooley, J.C. Wurzer, M. Megahy, G. Schreiber, T. Roy, G. Proulx, S. Laduzinsky, S. Lane, J. Dalzell, K. Dowlatshahi, D. Simmons, J.P. Thropay, H. Ahuja, P. Beitsch, R.W. Holt, and C. A. Lee, ”Electronic brachytherapy as adjuvant therapy for early stage breast cancer: a retrospective analysis”, Onco Targets Ther, vol.4, pp.13-20, 12 Jan. 2011. doi: 10.2147/OTT.S15297

[41] O. Ivanov, A. Dickler, B.Y. Lum, J.V. Pellicane, and D.S. Francescatti, ” Twelve-month follow-up results of a trial utilizing Axxent electronic brachytherapy to deliver intraoperative radiation therapy for early-stage breast cancer”, Ann Surg Oncol, vol.18, no.2, pp.453-458, Feb.2011.

[42] V.K. Mehta, O. Algan, K.L. Griem, A. Dickler, K. Haile, D.E. Wazer, R.E. Stevens, M. Chadha, S. Kurtzman, S.D. Modin, K. Dowlatshahi, K.W. Elliott, and T.W. Rusch, ” Experience with an electronic brachytherapy technique for intracavitary accelerated partial breast irradiation” Am J Clin Oncol, vol.33, no.4, pp.327-335, Aug. 2010.

[43] Y. Rong, and J.S. Welsh, ” Surface applicator calibration and commissioning of an electronic brachytherapy system for nonmelanoma skin cancer treatment”, Med Phys, vol.37, no.10, pp.5509-5517, Oct. 2010.

[44] Xoft, “Information for patients and their families”, available at http://www.xoftinc.com., 2013, Canada, accessed at 14 Nov. 2104.

[45] G. Gutman, E. Sozontov, E. Strumban, F. Yin, S. Lee, and J. H. Kim, ” A novel needle-based miniature x-ray generating system”, Phys. Med. Biol., vol. 49, no. 20, pp. 4677, doi:10.1088/0031-9155/49/20/001.

[46] S.M. Seltzer, M. O’Brien, and M. G. Mitch, ” New National Air-Kerma Standard for Low-Energy Electronic Brachytherapy Sources ”, Journal of Research of the National Institute of Standards and Technology, vol. 119, pp. 554-574, 2014, available at http://dx.doi.org/10.6028/jres.119.022