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IJSTR >> Volume 7 - Issue 10, October 2018 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Outcome Of Early Vs Late Antibiotic Administration In Management Of Patients With Severe Sepsis

[Full Text]



Shaheer Zahid



Sepsis, Antibiotic administration in the management of severe sepsis, microbial isolate from infection, site of infection, the mortality rate in sepsis, organ failure from sepsis.



Sepsis is a potentially life-threatening complication of an infection. Sepsis occurs when chemicals released into the bloodstream to fight the infection trigger inflammatory responses throughout the body. This inflammation can trigger a cascade of changes that can damage multiple organ systems, causing them to fail. With the increasing population at risk of sepsis in the United States, it has become crucial to recognize signs and symptoms of sepsis; also important is to refine and develop guidelines that will reduce the mortality. This study focused on the patients of Jackson Park hospital in the ER/ICU/Floors between Jan 1, 2014, and Dec 31, 2014, and compared the appropriateness of antibiotics, their administration time, microbial isolate and site of infection to the mortality rate seen amongst the patients. All the collected data were compared using tables, pie chart and bar graphs. The study showed patients receiving antibiotics within 3 hours of arrival to the ED had a reduction in mortality by 49% with sepsis from E. coli, MRSA & other staph infections were among the most common infections leading to mortality among the patients. Lungs and UTI infections were the most common site, with respiratory tract having 27% mortality among all patients presenting with sepsis. The study allowed a prompt evaluation of sepsis screening protocol, as well as developing new protocols to include certain antibiotics readily available in the ED and antibiogram to be done for all sepsis patients.



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