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IJSTR >> Volume 3- Issue 10, October 2014 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Synthesis And Identification 1-3 Diazepine From Ibuprofen

[Full Text]



Maysaloon Jawed Kadhim, Hassan Thamer Ghanim



Key word: Ibu profen,Schiffs base,oxazepine,diazepin,anti-inflammatory,non-steroid,nonselective



ABSTRACT: The research was involved preparation of 1-3 diazepin from 2-(4-isobutylphenyl) propanoic acid (ibuprofen) by many steps including[Schiff bases,1-3 Oxazepine and 1-3deazepine] ibuprofen was used a basic substance to prepare of these compounds, via many steps: the first Step including prepared ester from Ibuprofen in absolute Ethanol solvent in the presence H2SO4 con so the following derivative was produced (M1). Step two including prepared hydrazid derivatives from reaction the ester with NH2-NH2 H2O.80% in the absolute Ethanol solvent were produced(M2). In the next step, a new Schiff bases compound prepared by a condensed reaction of(M2) with Acetophenone and 4-chloro Acetophenone was produced (K1,K2). The third step includes preparation of two Oxazepine ring by a reaction of tow Schiff bases produced by the first with maleic anhydride in dry benzene solvent to give the compound(H1, H2). In the end step includes the preparation of two deazepine ring by reaction 1-3 oxazepine ring with phenyl hydrazine to product the compound(1,2).These synthesized compound have been characterized by melting point Elemental analysis FTIR and HMNR spectroscopy by their UN corrected melting points, elemental analysis and FT-IR spectra



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