Impact of Nanoparticle On Enzymes Activity In  Oreochromis Mossambicus

Abstract: Toxicity of Titanium dioxide nanoparticles (TiO2-NPs) to freshwater fish, Oreochromis mossambicus is assessed in this work. The endpoint of this study has focussed the disturbances in the vital enzyme profile of fish exposed to TiO2-NPs. Superoxide dismutase (SOD), Catalase (CAT), Peroxidase (POD) and Lipid per Oxidation (LPO) levels in brain, gill and liver tissues of tilapia were analysed and observed that these values were concentration and duration dependent. The results obtained in this study have projected a statistically significant decrease (P < 0.05) in SOD, CAT and POD activities and an increase (P < 0.05) in LPO levels in selected tissues of fish exposed to 50, 100 and 150 ppm TiO2-NPs. Further, this finding suggests that there is an oxidative stress in fish. Moreover, the depletion of antioxidant enzymes activities and the elevation of LPO in liver tissue are higher indicating that the liver might be the most susceptible organ to TiO2-NPs exposure. Thus hepatotoxicity is underlined in this work.

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