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IJSTR >> Volume 6 - Issue 10, October 2017 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Synthesis Of 3-Substituted-6, 8-Dibromo-2-Methyl Quinazolin-4(3H)-One Derivatives Via 6, 8-Dibromo-2-Methyl-4h-Benzo [D] [1,3] 朞xazin-4-One.

[Full Text]



Osarumwense, P.O, Edema, M.O, Usifoh, O, Marvis, E.



benzoxazinone, cylization, 3, 5-dibromoanthranilate, 6, 8-dibromo-2-Methyl-4H-benzo[d] [1, 3] 杘xazine-4-one, nitrogen nucleophile, synthesis, 3-substituted-6,8-dibromo-2-Methyl-quinazoline4(3H)-one.



The condensation of methyl 3, 5-dibromoanthranilate with acetic anhydride yielded the cyclic compound 2-Methyl-6, 8-dibromo-4H-benzo-oxazine-4-one which further produce a novel 2, 3-disubstituted quinazolin-4-ones via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of infrared, Nuclear Magnetic Resonance (1H and 13C), Gas chromatography Mass Spectrophotometer and Elemental analysis.



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