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IJSTR >> Volume 2- Issue 9, September 2013 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Synthesis And Characterization Of Some Metal Complexes Of Zn(II) With 1,10- Phenanthroline And Some Amino Acids: Anti-Inflammatory And Analgesic Activities Of Its Complexes.

[Full Text]



Md. Anwar Hossain, Md. Chanmiya Sheikh, SK AL Zaheri Mahmud, Md. Ashraful Alam



Keywards: Zinc, amino acids, 1,10-Phenanthroline, anti-inflammatory and analgesic activity, 1H-NMR, 13C-NMR and FAB+ mass



Abstract: New mixed ligand complexes of Zn(II) with 1,10- Phenanthroline and some amino acids were prepared in the solid form and characterized by elemental analysis, conductivity, magnetic moment measurement, FT-IR, 1H-NMR, 13C-NMR and FAB+ mass studies. To examine anti-inflammatory and analgesic activities of its complexes, some Swiss albino mice of 05-07 weeks old were taken. One dose of the test compounds of 10 mg/kg was selected throughout the research work. The anti-inflammatory activity of the test compounds were determined by 'carragenan induced mice paw edema inhibition' method, and however, the analgesic activity was determined by 'acetic acid induced writhing' methods. These four compounds showed positive effects as anti-inflammatory and analgesic agents. Anti-inflammatory and analgesic activities of the test compounds at 50 mg/kg were quite comparable to those of standard drugs at 10 mg/kg.



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