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IJSTR >> Volume 3- Issue 10, October 2014 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Study The Effect Of Zingiber Officinale Extract On The Serum Lipids In Rabbits

[Full Text]



Baha'a A. Abdul-Hussein



Keywords; Atrovastatin, Cholesterol, Ginger, Hyperlipidemia, HDL, LDL, TG, VLDL.



Abstract: The increasing in serum lipids and also the persistent hyperlipidemia concerned the main reason for many problems especially to the heart and arteries like atherosclerosis . Ginger or ginger root is the rhizome of the plant Zingiber officinale, consumed as a delicacy, medicine, or spice. Ginger has a cholesterol lowering properties.Aim of the study Its to evaluate the lipid lowering activity of ginger, and to compare the effect with the most known lipid regulating drug; atrovastatin. Materials and methodsA group of eleven New Zealand male rabbit (Oryctologus cuniculus) were subdivided into 3 groups each group included 4 rabbits; Group 1were received atrovastatin orally (1ml) for 10 days.Group2 were received zengiber (ginger) extract orally (1ml) for 10 days. Group 3 was control and received DW only, for 10 days. After the first 10 days; the fat was added to the diet (to induce increasing in blood cholesterol) and persisted to add daily for another 10 days, with continuation of atrovastatin and zengiber administration. Results Ginger extract caused highly significant reduction in cholesterol and level was 91.1±0.02 at 10th day. Also ginger highly significantly reduced the triglycerides and level was 95.2±0.01, the LDL was reduced by ginger highly significantly 51.1±0.01, the VLDL also reduced by ginger significantly 18.2±0.02, while the HDL level was kept by ginger extract, on the other hand the ginger extract was more efficient than atrovastatin in the lowering of lipids.



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