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IJSTR >> Volume 6 - Issue 6, June 2017 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Hepatoprotective Effect Of Crude Aqueous Leaf Extract Of Fig Tree, Ficus Benjamina, On Ethanol-Induced Liver Damage In Mice

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Aimee Lynne Pilapil, Normilando Luscano, Raizel Marie Luciano, Jeffrey Lumbres, Patricia Jin Maclan, Ivy Marie Managuelod, Erin Keshia Manlutac, Paolo Luis Paredes, Joana Punongbayan, Lailanie Jane Santiago, Pauline Dominique Sevilla, Beverly Joanne Tusca



Ethanol-induced hepatotoxicity, Ficus benjamina, Mice



Alcoholic abuse remains to be the most common cause of liver cirrhosis with significant morbidity and mortality worldwide. Herbal supplements are being used to prevent damage in excessive alcohol intake and including hepatitis from other causes as hepatoprotective agents. Fig tree is currently being utilized in studies as a potential candidate for hepatoprotection but with limited success. This study determined the hepatoprotective effect of crude aqueous leaf extract of fig tree, Ficus benjamina, on ethanol-induced hepatotoxicity in mice. In this study, fifteen Balb/c mice were assigned to negative control, positive control and treatment groups which received distilled water, Silymarin, and F. benjamina crude aqueous leaf extract respectively on day 0 to day 14. Ethanol-induced hepatotoxicity was done on day 7 to day 14 using ethanol given by oral gavage. Assessment of liver function and histology was done with the use of alanine aminotransferase (ALT) assay and histopathological study respectively. Results showed significant reduction of ALT levels in the treatment (52.40 U/L) and the positive control groups (42.58 U/L) as compared with the negative control group with a mean of 196.88 U/L (P<0.05). The difference between the positive and treatment groups was not significant (P>0.05). The degree of hepatic injury was significantly severe in the negative control group than with the treatment and positive control groups (P<0.05). On the other hand, the degree of hepatic injury showed no significant difference between the positive and treatment groups (P>0.05). Thus, the crude aqueous leaf extract of F. benjamina has hepatoprotective property on ethanol-induced hepatotoxicity in mice, similar to Silymarin. F. benjamina, as an ornamental plant, may be a source of phytochemical with potential pharmaceutical and functional activities.



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