International Journal of Scientific & Technology Research

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IJSTR >> Volume 3- Issue 4, April 2014 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Nephrogenic Adenoma Of The Bladder: A Case Report

[Full Text]



Y. Essatara, M.Asseban, M.H. Benazzouz, H. El Sayegh, A. Iken, L. Benslimane, K.Znati, Y. Nouini





Abstract: Nephrogenic metaplasia is a benign tumor characterized by urothelial tubulo - papillary structures. It is also called nephrogenic adenoma. It is a benin lesion and highly prone to recurrency. We report a case of a bladder nephrogenic metaplasia of a 65 years old patient with hematuria and POLLAKIURIA. Clinical examination was normal. Ultrasonography showed a circumferential thickening bladder, while cystoscopy showed a tumor at the dome and the right side. A transurethral resection of the bladder was performed. Histological study concluded at the existence of nephrogenic metaplasia of the bladder mucosa. The evolution was favorable and postoperative controls, including cystoscopy and intravenous urography (IVU ) at 1, 3 and 6 months were normal.



[1] GERRIDZEN R.G., DE JESUS F., WESLEY JAMES T., SCHILLINGER J.F. Nephrogenic adenoma with bladder extrophy and immunosuppression. Urology, 1991, 38, 345-346.

[2] HUSAIN A.N., MARIN A.R., SCHUSTER G.A. Nephrogenic metaplasia of urinary tract in children: Report of three cases and review of the literature. Pediat. Pathol., 1988, 8, 293-300.


[4] NOLD S.R., TERRY W.J., CERNIGLIA F.R., HAWKINS E.P.,ROTH D.R., GONZALES E.T. Nephrogenic adenoma of the bladder in children, J. Urol., 1989, 142, 1545-1547

[5] STEFFENS J., SEITZ G., WERNERT N., ALLOUSSI S., ZIEGLERM. Nephrogenic adenoma of the bladder in a child – immunohistochemical and le ctinhisto-chemical investigations. Eur. Urol.1990, 18, 64-67.

[6] ZIMMERMANN K., AMIS E.S. J.R., NEWHOUSE J.H. Nephrogenic adenoma of the bladder: urographic spectrum. Urol. Radiol., 1989, 11, 123-126

[7] FOURNIER G.: Métaplasie néphrogène de l’appareil urinaire. Prog. Urol., 1996; 6: 861-868.

[8] McINTIRE T., SOLOWAY M.S., MURPHYW.M.: Nephrogenic adenoma.Urology, 1987 ; 29: 237-241.

[9] PEEKER R.,ALDENBORG F., FA L L M.: Nephrogenic adenoma. A study with special reference to clinical presentation.Br. J. Urol., 1997 ; 80: 539-542.

[10] BENCHEKROUN A., LACHKAR A., BEN SLIMAN L., BELAHNECH Z., MARZOUK M., FAIK M.: Métaplasie néphrogénique de l’uretère. Prog. Urol., 2000 ; 10: 287-290.

[11] GOKASLAN S.T., KRUEGER J.E., ALBORES-SAAVEDRA J.: Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical,study of four cases. Mol. Pathol., 2002 ; 15: 765-770.

[12] ALLAN C.H., EPSTEIN J.I.: Nephrogenic adenoma of the prostatic urethra: ba mimicker of prostate adenocarcinoma. Am. J. Surg. Pathol., 2001 ; 25: 802-808

[13] HEFFERNAN J.P., HUISMAN T.K.: Nephrogenic adenoma in a bladder diverticulum. J. Urol., 1994 ; 152: 1208-1210.

[14] ODZE R., BEGIN L.R.: Tubular adenomatous metaplasia (nephrogenic adenoma) of the female urethra. Int. J. Gynecol. Pathol., 1989 ; 8: 374-380.

[15] GARCIA-PENIT J., ORSOLA A., PARADA R., ALGABAF., GARAT J.M.: Synchronous nephrogenic adenoma in the bladder and neourethra (bladder mucosa) in a boy. BJU International., 1999 ; 84: 169-170.

[16] DAVIS T.A.: Hamartoma of the urinary bladder. Northwest. Med., 1949 ; 48: 182-185.

[17] WEINGARTNER K., KOZAKEWICH H.P., HENDREN W.H.: Nephrogenic adenoma after urethral reconstruction using bladder mucosa: report of 6 cases and review of the literature. J. Urol., 1997 ; 158: 1175-1177.

[18] GOLDMAN H.B., DMOCHOWSKI R.R., NOE H.N.: Nephrogenic adenoma occurring in an augmented bladder. J. Urol., 1996 ; 155: 1410.

[19] TSE V., KHADRA M., EISINGER D., MITTERDORFER A., BOULAS J., ROGERS J.: Nephrogenic adenoma of the bladder in renal transplant and non-renal transplant patients: a review of 22 cases. Urology, 1997 ; 50: 690- 696.

[20] THONG W., HINSCH R., CLOUSTON A., NICOL D.: Nephrogenic metaplasia: long-term haemodialysis and anuria as potential risk factor and reversibility with renal transplantation. Nephrol. Dial. Transplant., 1995 ; 10: 2101-2103.

[21] STILMANT M.M., SIROKY M.B.: Nephrogenic adenoma associated with intravesical bacillus Calmette-Guérin treatment: A report of 2 cases. J. Urol., 1986 ; 135: 359-361.

[22] WOOD D.P., STREEM S.B., LEVIN H.S.: Nephrogenic adenoma in patients with transitional cell carcinoma of the bladder receiving intravesical thiotepa. J. Urol., 1988 ; 139: 130-131.

[23] MOSTOFI F.K. Potentiali ties of b ladder epi thel ium. J. Urol. (Baltimore), 1954, 71, 705-714.

[24] BILLEREY C., KHAMLU K., REGIN J.P., BITTARD M., OPPERMANN A.: La métaplasie néphrogénique de la muqueuse urothéliale. A propos de onze observations. Ann. Urol., 1983,17, 340-346.

[25] GONZALEZ J.A., WATTS J.C., ALDERSON T.P.: Nephrogenic adenoma of the bladder: report of 10 cases. J. Urol., 1988 ; 139: 45-47.