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IJSTR >> Volume 2- Issue 4, April 2013 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Lipid Profile In Ghanaian Women With Gestational Diabetes Mellitus

[Full Text]



H. Asare-Anane, A.T. Bawah , B. Osa-Andrews , R Adanu, E.K. Ofori, S.A Bani R.O Ateko E.A. Tagoe, A.K. Nyarko



KEY WORDS: - Cholesterol, Cortisol, Gestational Diabetes Mellitus, Impaired Fasting Glycaemia, Insulin Resistance, Preeclampsia, Progesterone, Very Low Density Lipoprotein-



Abstract: - Lipid profile has been a useful tool for the efficient screening and management of patients with diabetes mellitus. Lipid profile changes associated with gestational diabetes mellitus (GDM) are well documented in other parts of the world but not in Ghana. The role of plasma lipids in the pathogenesis of GDM in Ghanaian women was investigated. Ante-natal patients were selected as a case control study including 100 patients with GDM (cases) and 100 pregnant women without GDM (control). Mean values (GDMs vs controls in mmol/L) of TG (2.29± 0.07 vs 1.75±0.08, p<0.001), TCHOL (7.26±0.16 vs 5.85±1.65, p<0.001), LDL (4.71 ± 0.17 vs 3.83±0.16 p<0.001), and VLDL (1.12±0.03 vs 0.80±0.04 p<0.001), respectively were significantly higher in GDMs than the controls. Mean HDL for the GDMs was significantly lower in GDMs compared to controls (1.2±0.07 vs 1.46±0.08 p=0.023). Mean cortisol concentration for GDMs (509±12.02ng/ml) was significantly higher than controls (402.70±13.12ng/ml) (p<0.05). Also, mean progesterone was significantly higher in GDMs (46.41±2.75ng/ml) than controls (33.06±1.66ng/ml) (p<0.05). These study showed that generally, lipid parameters [LDL, total cholesterol, VLDL) were significantly higher in GDMs compared with controls. However, HDL was significantly higher in controls compared with GDM.



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