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IJSTR >> Volume 2- Issue 4, April 2013 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Variability Of Iron Metabolism During Pregnancy In Women With HIV On Antiretroviral Therapy In Abidjan (Cote d'Ivoire)

[Full Text]



Mathieu Nahounou BLEYERE, Soualio KAMAGATE, Leandre Kouakou KOUAKOU, Sylvie DOUMATEY, Paul Angoue YAPO



Keywords: Iron metabolism; inflammatory anaemia; Pregnancy; HIV; Antiretroviral therapy; Abidjan (Côte d'Ivoire)



ABSTRACT: - OBJECTIVES: The aim of this study is to evaluate and characterize the iron metabolism in women during pregnancy living with HIV and following antiretroviral therapy. METHODOLOGY: In this context, 140 HIV positive pregnant women followed at the Integrated Centre for Bioclinical Research of Abidjan were enrolled. Their average age was 34.7 ± 0.5 years ranging from 18 to 45 years. Blood samples in tubes with anticoagulant and dry tubes were performed in each of selected women. Assays were carried out to determine assessment biological parameters of iron status. Programs Statistica Statsoft Windows version 7.1 and R 2.0.1 version Windows were used for statistical analyzes of data. The level of significance was defined for a p value < 0.05. RESULTS: The results of our investigations showed heterogeneity of all biological parameters except haematological indicators. In addition, evaluation of the biological parameters reported that 100% of women in the first trimester of pregnancy showed an abnormal iron status. This abnormal status consisted of iron deficiency, iron deficiency anaemia and inflammatory anaemia. This type of anaemia was highly observed with 90 % in early of pregnancy, 80 % in second and third trimesters of pregnancy respectively. This anaemia has been associated with evolutive stages of immunosuppression. However, no inflammatory anaemia associated with iron deficiency has been reported in subjects during pregnancy. CONCLUSION: In total, our observations indicated that iron metabolism was strongly altered during pregnancy among women infected with HIV.



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